Among the multiple uses analysis of tweets can have, safety surveillance, signal detection and discovery of adverse drug events or adverse drug reactions is something that we are just starting to explore for pharmacovigilance analyticsin the framework of social media analysis. In this post, we are going to analyze all papers retrieved from PubMed with the search string: On 02 Marchthat search resulted in 79 search results.
Abstract Background Dronedarone is FDA approved for the treatment of patients with atrial fibrillation AF as a safe alternative to amiodarone. There are no full-length published papers describing the effectiveness of acute dronedarone against AF in experimental or clinical studies.
Methods We determined the effect of acute dronedarone and amiodarone on electrophysiological parameters, and their anti-AF efficacy in canine isolated arterially-perfused right atria.
Transmembrane action potentials and pseudo-ECGs were recorded. Conclusions The electrophysiological effects and anti-AF efficacy of acute dronedarone are much weaker than those of amiodarone in a canine model of AF.
The efficacy of acute dronedarone to prevent induction of acetylcholine-mediated AF as well as to terminate persistent AF in canine Dronedarone essay atria is relatively poor. Our data suggest that acute dronedarone is a poor substitute for amiodarone for acute cardioversion of AF or prevention of AF recurrence.
Dronedarone is an amiodarone derivative that lacks the iodine moiety which is believed to be responsible for the toxicity of amiodarone.
Available data indicate that long-term use of dronedarone is generally safer than that of amiodarone, but that its efficacy to maintain sinus rhythm is considerably lower than that of amiodarone. The main objective of the current study was to directly compare the acute electrophysiological effects of dronedarone and amiodarone, and their anti-AF potency in a canine model of AF.
Three-fourths of both ventricles were quickly removed. The ostium of the right coronary artery was cannulated with polyethylene tubing i. With continuous coronary perfusion, all ventricular branches of the right coronary artery were immediately clamped with metal clips.
Ventricular right coronary branches as well as the cut atrial branches were ligated using silk thread. Electrophysiological assessments Transmembrane action potential AP recordings were obtained using floating glass microelectrodes 2.
The signals were displayed on oscilloscopes, amplified, digitized and analyzed Spike 2, Cambridge Electronic Design, Cambridge, England. The diastolic threshold of excitation DTE was determined by increasing stimulus intensity in 0.
The effective refractory period ERP was measured by delivering premature stimuli after every 10th regular beat at a pacing cycle length CL of ms with 5 to 10 ms resolution; stimulation with a 2 x DTE amplitude. Stable AP recordings and Vmax measurements are difficult to obtain in vigorously contracting perfused preparations.
A large variability in VMax measurements is normally encountered at any given condition, primarily due to variability in the amplitude of phase 0 of the AP which strongly determines VMax values.
The effects of amiodarone and dronedarone on Vmax were determined by comparing the largest Vmax recorded under any given condition. Due to a substantial inter-preparation variability, Vmax values were normalized for each experiment and then averaged.
Experimental protocols Coronary-perfused atrial preparations were equilibrated in the tissue bath until electrically stable, usually 30 min. The preparations were paced at a CL of ms, using a pair of thin silver electrodes insulated except at their tips bipolar rectangular pulses of 2 ms duration and twice DTE intensity.
At least 30 min were allowed for each concentration of dronedarone and amiodarone to act before the start of data collection. In the second set, persistent AF was induced first in the presence of ACh, 1. If AF was terminated, re-induction of the arrhythmia was attempted.Dronedarone is FDA approved for the treatment of patients with atrial fibrillation (AF) as a safe alternative to amiodarone.
There are no full-length published papers describing the effectiveness of acute dronedarone against AF in experimental or clinical studies. Comparative Efﬁcacy of Dronedarone CME and Amiodarone for the Maintenance of Dronedarone is a noniodinated benzofuran similar to ami- The full papers for the remaining 8 published trials were retrieved for detailed review and abstraction.
The results of the DIONYSOS.
The author, a nurse practitioner based in an Emergency Department (ED), from here on in will be referred to as ‘the practitioner’.
The practitioner is currently employed in a development role with the view, following training, of becoming an acute care practitioner.
This will entail working. Dronedarone is a Class III antiarrhythmic and a multi-channel blocker for atrial fibrillation. It blocks potassium, sodium, and calcium channels and also exhibits antiadrenergic properties. Safety . In conclusion, use of dronedarone for prophylaxis of AF recurrences is not associated with an increased risk of death, either cardiovascular or total, and combination with digoxin should be.
Multaq (dronedarone) is a benzofuran derivative with antiarrhythmic properties belonging to all four Vaughan-Williams classes. The exact mechanism of action is unknown. Dronedarone is a derivative of amiodarone, an effective yet toxic antiarrhythmic drug.